Development and patent synthesis of nirmatrelvir - the main component of the first oral drug against SARS-CoV-2 Paxlovid (R)

Nirmatrelvir is the main component of the first oral drug against SARS-CoV-2 called Paxlovid (R). Its development from an orally unavailable predecessor through hydrogen bond donors (HBD) replacement is highlighted, followed by an examination of the synthetic routes described in the original PCT application WO2021/250648. Based on its attributes, nirmatrelvir shows the potential to be a game changer in SARS-CoV-2 treatment.

Let's Talk About Stereochemistry for a Moment: A Home Experiment Conducted with College Students in Social Isolation

Due to COVID-19, we are adjusting to a new educational environment while also being socially isolated. By combining previously established ways of remote education with video conferences, the world is creating a new sector termed techno-pedagogy. The concept of stereochemistry in Organic Chemistry is frequently difficult to understand even in classroom teaching. Plane-polarized light rotation is difficult to describe because it needs a high level of ion in the mental exercise. As a result, we propose in this work that technology be developed to teach stereochemistry remotely. As a result, we prepared a training video that shows college students how to execute a hand-made stereochemistry experiment. Lecturers, undergraduates, and graduate students all gave the video great scores. © 2022, Universidade Federal de Mato Grosso do Sul, Departamento de Quimica. All rights reserved.